Article

Dissecting the molecular landscape of Parkinson’s disease and Parkinson’s disease dementia using highly efficient snRNA-seq (HIF-snRNA-seq)

2025-03-07

Abstract excerpt

This study presents a transcriptomic analysis of the cingulate cortex (CING) in Parkinson’s disease (PD) and Parkinson’s disease dementia (PDD) using a High-efficiency single-nucleus RNA sequencing (HiF-snRNA-seq) protocol optimized for post-mortem brain samples. RNA quality prediction, poly-A tailing, and dCas9-targeted depletion enabled analysis of 77 high-quality samples from 240 cases, yielding over 2 million...

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Literature Corpus work: a02c5d0f-5a6d-529d-ab44-2a45a285d5fb
DOI: 10.1101/2025.03.01.640894

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