Article

Cellular type is a major determinant of R-loop genomic distribution

2025-04-17

Abstract excerpt

R-loops containing a DNA:RNA hybrid and unpaired single-stranded DNA are important for normal cell physiology and pathogenesis of numerous diseases. Although several different approaches for R-loop mapping have been developed, these techniques can produce conflicting results. In order to assess their robustness, a study by Chedin et al compared a number of R-loop datasets obtained using different methodologies fro...

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Literature Corpus work: bd8419bd-79e0-55f5-8eae-e6a25d52d905
DOI: 10.1101/2025.04.17.649299

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