Article
Quantitative model of R-loop forming structures reveals a novel level of RNA-DNA interactome complexity.
Nucleic acids research - 1 Jan 2012
Wongsurawat Thidathip, Jenjaroenpun Piroon, Kwoh Chee Keong, Kuznetsov Vladimir
Abstract excerpt
R-loop is the structure co-transcriptionally formed between nascent RNA transcript and DNA template, leaving the non-transcribed DNA strand unpaired. This structure can be involved in the hyper-mutation and dsDNA breaks in mammalian immunoglobulin (Ig) genes, oncogenes and neurodegenerative disease related genes. R-loops have not been studied at the genome scale yet. To identify the R-loops, we developed a...
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