Article

qDRIP: Quantitative differential RNA:DNA hybrid immunoprecipitation sequencing

2019-10-21

Abstract excerpt

R-loops are dynamic, co-transcriptional nucleic acid structures that facilitate physiological processes and cause DNA damage in certain contexts. Perturbations of transcription or R-loop resolution are expected to change their genomic distribution. Next-generation sequencing approaches to map RNA:DNA hybrids, a component of R-loops, have so far not allowed quantitative comparisons between such conditions. Here we...

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Literature Corpus work: d87c299d-a793-5f91-aebe-30970bb7e3a7
DOI: 10.1101/811208

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