Back to search

Article

The complete diploid reference genome of RPE-1 identifies human phased epigenetic landscapes

2023-11-03

Abstract excerpt

<h4>SUMMARY</h4> Comparative analysis of recent human genome assemblies highlights profound sequence divergence that peaks within polymorphic loci such as centromeres. This raises the question about the adequacy of relying on human reference genomes to accurately analyze sequencing data derived from experimental cell lines. Here, we generated the complete diploid genome assembly for the human retinal epithelial c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c1076189-024d-5656-bfb0-138bfd36b837
DOI
10.1101/2023.11.01.565049
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The complete diploid reference genome of RPE-1 identifies human phased epigenetic landscapesDOI 10.1101/2023.11.01.565049
Complete genomic and epigenetic maps of human centromeresSemantic proximity
The diploid reference genome of a human embryonic stem cell lineSemantic proximity
The complete sequence of a human genomeSemantic proximity
Fully T2T pedigree assemblies reveal genetic stability and epigenetic plasticity of human centromeres across inheritance and cell-fate transitionsSemantic proximity
Complex genetic variation in nearly complete human genomesSemantic proximity
Complete genomes of a multi-generational pedigree to expand studies of genetic and epigenetic inheritanceSemantic proximity
A Telomere-to-Telomere Diploid Reference Genome and Centromere Structure of the Chinese QuartetSemantic proximity
Semi-automated assembly of high-quality diploid human reference genomes.Semantic proximity
Automated assembly of high-quality diploid human reference genomesSemantic proximity
Establishment of an eHAP1 Human Haploid Cell Line Hybrid Reference Genome Assembled from Short and Long ReadsSemantic proximity
Epigenetic Patterns in a Complete Human GenomeSemantic proximity
Personalized reference genome-based pipeline reveals comprehensive haplotype-resolved views of cancer genomesSemantic proximity
Select a neighboring publication to make it the new centre.