Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Live-cell imaging unveils distinct R-loop populations with heterogeneous dynamics

11 Oct 2023

Abstract excerpt

We have developed RHINO, a genetically encoded sensor that selectively binds RNA:DNA hybrids enabling live-cell imaging of cellular R-loops. RHINO comprises a tandem array of three copies of the RNA:DNA hybrid binding domain of human RNase H1 connected by optimized linker segments and fused to a fluorescent protein. This tool allows the measurement of R-loop abundance and dynamics in live cells with high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genomics and Chromatin Dynamics
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37819055
DOI: 10.1093/nar/gkad812

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Live-cell imaging unveils distinct R-loop populations with heterogeneous dynamicsPMID 37819055Read ↗

Out of balance: R-loops in human disease.Semantic proximity Read ↗

Variability in R-loops levels based on IHC detectionSemantic proximity Read ↗

Genome-wide mapping of native co-localized G4s and R-loops in living cellsSemantic proximity Read ↗

Cellular type is a major determinant of R-loop genomic distributionSemantic proximity Read ↗

BisMapR: a strand-specific, nuclease-based method for genome-wide R-loop detectionSemantic proximity Read ↗

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA DamageSemantic proximity Read ↗

Recognition of cellular RNAs by the S9.6 antibody creates pervasive artefacts when imaging RNA:DNA hybridsSemantic proximity Read ↗

qDRIP: Quantitative differential RNA:DNA hybrid immunoprecipitation sequencingSemantic proximity Read ↗

Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replicationSemantic proximity Read ↗

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instabilitySemantic proximity Read ↗

Understanding and re-engineering nucleoprotein machines to cure human disease.Semantic proximity Read ↗

Protein-mediated stabilization and nicking of the non-template DNA strand dramatically affect R-loop formation <i>in vitro</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.