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Article

CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data.

Genome biology - 15 Jun 2016

Cairns Jonathan, Freire-Pritchett Paula, Wingett Steven W, Várnai Csilla, Dimond Andrew, Plagnol Vincent, Zerbino Daniel, Schoenfelder Stefan, Javierre Biola-Maria, Osborne Cameron, Fraser Peter, Spivakov Mikhail

Abstract excerpt

Capture Hi-C (CHi-C) is a method for profiling chromosomal interactions involving targeted regions of interest, such as gene promoters, globally and at high resolution. Signal detection in CHi-C data involves a number of statistical challenges that are not observed when using other Hi-C-like techniques. We present a background model and algorithms for normalisation and multiple testing that are specifically...

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Identifiers

PMID: 27306882
DOI: 10.1186/s13059-016-0992-2
PMCID: PMC4908757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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