Article

Spatial co-fragmentation pattern of cell-free DNA recapitulates <i>in vivo</i> chromatin organization and identifies tissues-of-origin

2019-10-23

Abstract excerpt

<h4>ABSTRACT</h4> Three-dimensional chromatin organization varies across cell types and is essential for gene regulation. However, current technologies are unable to assess in vivo genome-wide chromatin organization non-invasively. Here we show that distant correlations in the fragment length of cell-free DNA (cfDNA) recapitulate three-dimensional chromatin organization. The inferred organization is highly conco...

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Literature Corpus work: a2381a38-cf08-5120-9e9c-b2fa3ecd88e2
DOI: 10.1101/564773

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