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Article

Cell-stereotyped DNA repair outcomes are widespread during genome editing

2025-10-23

Abstract excerpt

<h4>Summary</h4> Genome editing outcomes are governed by DNA repair pathways that vary with cell type and state. We developed scOUT-seq (single-cell Outcomes Using Transcript sequencing), a scalable approach that jointly profiles transcriptomes and matched multi-allelic editing outcomes ranging from homology directed repair (HDR) to inter-chromosomal translocations. We mapped editing outcomes in human CD34⁺ hemat...

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Literature Corpus work
a3d68e97-5363-517b-8c11-b98038045b7d
DOI
10.1101/2025.10.23.684114
Open publication

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Cell-stereotyped DNA repair outcomes are widespread during genome editingDOI 10.1101/2025.10.23.684114
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