Article

Complex small-world regulatory networks emerge from the 3D organisation of the human genome

2020-05-14

Abstract excerpt

The discovery that overexpressing one or a few critical transcription factors can switch cell state suggests that gene regulatory networks are relatively simple. In contrast, genome-wide association studies (GWAS) point to complex phenotypes being determined by hundreds of loci that rarely encode transcription factors and which individually have small effects. Here, we use computer simulations and a simple fitting...

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Literature Corpus work: bd754f5d-caab-5124-a380-badb5117d7a1
DOI: 10.1101/2020.05.12.091041

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