Article

Cluster size determines internal structure of transcription factories in human cells

2023-01-18

Abstract excerpt

Transcription is a fundamental cellular process, and the first step of gene expression. In human cells, it depends on the binding to chromatin of various proteins, including RNA polymerases and numerous transcription factors (TFs). Observations indicate that these proteins tend to form macromolecular clusters, known as transcription factories , whose morphology and composition is still debated. While some microsc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2c48a2e8-70bb-5770-9671-bb576664e533
DOI: 10.1101/2023.01.16.524198

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cluster size determines internal structure of transcription factories in human cellsDOI 10.1101/2023.01.16.524198Read

Complex small-world regulatory networks emerge from the 3D organisation of the human genomeSemantic proximity Read

Complex small-world regulatory networks emerge from the 3D organisation of the human genomeSemantic proximity Read

RNA polymerase II initiation factors show different dynamic behaviour upon induced transcription in live cellsSemantic proximity Read

Transcription-induced active forces suppress chromatin motionSemantic proximity Read

Uncovering High-Resolution Organization of Genomic Loci using Experimentally Informed Polymer ModelSemantic proximity Read

Minimalistic 3D Chromatin Models: Sparse Interactions in Single Cells Drive the Chromatin Fold and Form Many-Body UnitsSemantic proximity Read

Principles of transcription factor traffic on folded chromatinSemantic proximity Read

Gene structure heterogeneity drives transcription noise within human chromosomesSemantic proximity Read

A Polymer Physics Model to Dissect Genome Organization in Healthy and Pathological Phenotypes.Semantic proximity Read

Transcription factors organize into functional groups on the linear genome and in 3D chromatinSemantic proximity Read

A Physics-based Model Reveals Mechanisms of Epigenetic MemorySemantic proximity Read

The Detailed 3D Multi-Loop Aggregate/Rosette Chromatin Architecture and Functional Dynamic Organization of the Human and Mouse GenomesSemantic proximity Read