Article

Complex small-world regulatory networks emerge from the 3D organisation of the human genome

2021-06-12

Abstract excerpt

<title>Abstract</title> <p>The discovery that overexpressing one or a few critical transcription factors can switch cell state suggests that gene regulatory networks are relatively simple. In contrast, genome-wide association studies (GWAS) point to complex phenotypes being determined by hundreds of loci that rarely encode transcription factors and which in- dividually have small effects. Here, we use computer si...

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Literature Corpus work: 929bb491-7ae0-5bd0-92ea-82e74be37f2b
DOI: 10.21203/rs.3.rs-566854/v1

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