Article

Evaluating brain structure traits as endophenotypes using polygenicity and discoverability

2020-07-17

Abstract excerpt

Human brain structure traits have been hypothesized to be broad endophenotypes for neuropsychiatric disorders, implying that brain structure traits are comparatively ‘closer to the underlying biology’. Genome-wide association studies from large sample sizes allow for the comparison of common variant genetic architectures between traits to test the evidence supporting this claim. Endophenotypes, compared to neurops...

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Literature Corpus work: bd647646-0be3-561e-89ce-59ded022f2ea
DOI: 10.1101/2020.07.17.208843

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