Article
Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis.
Schizophrenia bulletin - 29 Nov 2023
Wang Baihan, Irizar Haritz, Thygesen Johan H, Zartaloudi Eirini, Austin-Zimmerman Isabelle, Bhat Anjali, Harju-Seppänen Jasmine, Pain Oliver, Bass Nick, Gkofa Vasiliki, Alizadeh Behrooz Z, van Amelsvoort Therese, Arranz Maria J, Bender Stephan, Cahn Wiepke, Stella Calafato Maria, Crespo-Facorro Benedicto, Di Forti Marta, Giegling Ina, de Haan Lieuwe, Hall Jeremy, Hall Mei-Hua, van Haren Neeltje, Iyegbe Conrad, Kahn René S, Kravariti Eugenia, Lawrie Stephen M, Lin Kuang, Luykx Jurjen J, Mata Ignacio, McDonald Colm, McIntosh Andrew M, Murray Robin M, Picchioni Marco, Powell John, Prata Diana P, Rujescu Dan, Rutten Bart P F, Shaikh Madiha, Simons Claudia J P, Toulopoulou Timothea, Weisbrod Matthias, van Winkel Ruud, Kuchenbaecker Karoline, McQuillin Andrew, Bramon Elvira
Abstract excerpt
BACKGROUND AND HYPOTHESIS: Endophenotypes can help to bridge the gap between psychosis and its genetic predispositions, but their underlying mechanisms remain largely unknown. This study aims to identify biological mechanisms that are relevant to the endophenotypes for psychosis, by partitioning polygenic risk scores into specific gene sets and testing their associations with endophenotypes. STUDY DESIGN: We...
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