Article

Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture

2023-10-03

Abstract excerpt

<title>Abstract</title> <p>Genetic contributions to human cortical structure manifest pervasive pleiotropy. This pleiotropy may be harnessed to identify unique genetically-informed parcellations of the cortex that are neurobiologically distinct from functional, cytoarchitectural, or other cortical parcellation schemes. We investigated genetic pleiotropy by applying genomic structural equation modeling (SEM) to ma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd596eba-4a0d-586b-b659-1e2e5e30412f
DOI: 10.21203/rs.3.rs-3253035/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic ArchitectureDOI 10.21203/rs.3.rs-3253035/v1Read

Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture.Semantic proximity Read

Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic ArchitectureSemantic proximity Read

Joint modeling of human cortical structure: Genetic correlation network and composite-trait genetic correlation.Semantic proximity Read

Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface areaSemantic proximity Read

The genetic architecture of the human cerebral cortexSemantic proximity Read

The Genetic Architecture of Brain Structure and Function: A Data-Driven Interpretation Using genomICASemantic proximity Read

Quantifying the Polygenic Architecture of the Human Cerebral Cortex: Extensive Genetic Overlap between Cortical Thickness and Surface AreaSemantic proximity Read

Heritability of individualized cortical network topographySemantic proximity Read

The genetics of cortical organisation and development: a study of 2,347 neuroimaging phenotypesSemantic proximity Read

Mapping genetic influences on human brain structure.Semantic proximity Read

Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes.Semantic proximity Read

Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortexSemantic proximity Read