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Article

The endophenotype concept in psychiatry: etymology and strategic intentions.

The American journal of psychiatry - 1 Apr 2003

Gottesman Irving I, Gould Todd D

Abstract excerpt

Endophenotypes, measurable components unseen by the unaided eye along the pathway between disease and distal genotype, have emerged as an important concept in the study of complex neuropsychiatric diseases. An endophenotype may be neurophysiological, biochemical, endocrinological, neuroanatomical, cognitive, or neuropsychological (including configured self-report data) in nature. Endophenotypes represent simpler...

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Identifiers

PMID: 12668349
DOI: 10.1176/appi.ajp.160.4.636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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