Article
Polygenic Architecture of Human Neuroanatomical Diversity.
Cerebral cortex (New York, N.Y. : 1991) - 14 Apr 2020
Biton Anne, Traut Nicolas, Poline Jean-Baptiste, Aribisala Benjamin S, Bastin Mark E, Bülow Robin, Cox Simon R, Deary Ian J, Fukunaga Masaki, Grabe Hans J, Hagenaars Saskia, Hashimoto Ryota, Kikuchi Masataka, Muñoz Maniega Susana, Nauck Matthias, Royle Natalie A, Teumer Alexander, Valdés Hernández Maria, Völker Uwe, Wardlaw Joanna M, Wittfeld Katharina, Yamamori Hidenaga, Bourgeron Thomas, Toro Roberto
Abstract excerpt
We analyzed the genomic architecture of neuroanatomical diversity using magnetic resonance imaging and single nucleotide polymorphism (SNP) data from >26 000 individuals from the UK Biobank project and 5 other projects that had previously participated in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our results confirm the polygenic architecture of neuroanatomical diversity, with...
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