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Article

Exploring the genetic architecture of brain structure and ADHD using polygenic neuroimaging-derived scores.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2025

van der Es Tim, Soheili-Nezhad Sourena, Roth Mota Nina, Franke Barbara, Buitelaar Jan, Sprooten Emma

Abstract excerpt

Genome-wide association studies (GWAS) have provided valuable insights into the genetic basis of neuropsychiatric disorders and highlighted their complexity. Careful consideration of the polygenicity and complex genetic architecture could aid in the understanding of the underlying brain mechanisms. We introduce an innovative approach to polygenic scoring, utilizing imaging-derived phenotypes (IDPs) to predict a...

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Identifiers

PMID: 39016115
DOI: 10.1002/ajmg.b.32987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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