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Article

Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders.

Nature biomedical engineering - 1 Nov 2025

Wen Junhao, Skampardoni Ioanna, Tian Ye Ella, Yang Zhijian, Cui Yuhan, Erus Guray, Hwang Gyujoon, Varol Erdem, Boquet-Pujadas Aleix, Chand Ganesh B, Nasrallah Ilya M, Satterthwaite Theodore D, Shou Haochang, Shen Li, Toga Arthur W, Zalesky Andrew, Davatzikos Christos

Abstract excerpt

Recent work leveraging artificial intelligence has offered promise to dissect disease heterogeneity by identifying complex intermediate brain phenotypes, called dimensional neuroimaging endophenotypes (DNEs). We advance the argument that these DNEs capture the degree of expression of respective neuroanatomical patterns measured, offering a dimensional neuroanatomical representation for studying disease...

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Identifiers

PMID: 40481237
DOI: 10.1038/s41551-025-01412-w
PMCID: PMC12955822

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