Article
Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture.
Translational psychiatry - 24 Oct 2024
Morey Rajendra A, Zheng Yuanchao, Bayly Henry, Sun Delin, Garrett Melanie E, Gasperi Marianna, Maihofer Adam X, Baird C Lexi, Grasby Katrina L, Huggins Ashley A, Haswell Courtney C, Thompson Paul M, Medland Sarah, Gustavson Daniel E, Panizzon Matthew S, Kremen William S, Nievergelt Caroline M, Ashley-Koch Allison E, Logue Mark W
Abstract excerpt
Genetic contributions to human cortical structure manifest pervasive pleiotropy. This pleiotropy may be harnessed to identify unique genetically-informed parcellations of the cortex that are neurobiologically distinct from functional, cytoarchitectural, or other cortical parcellation schemes. We investigated genetic pleiotropy by applying genomic structural equation modeling (SEM) to map the genetic architecture...
Topics
- Humans
- Genome-Wide Association Study
- Cerebral Cortex
- Phenotype
- Latent Class Analysis
- Bipolar Disorder
- Genetic Pleiotropy
- Magnetic Resonance Imaging