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Article

Evaluating brain structure traits as endophenotypes using polygenicity and discoverability.

Human brain mapping - 1 Jan 2022

Matoba Nana, Love Michael I, Stein Jason L

Abstract excerpt

Human brain structure traits have been hypothesized to be broad endophenotypes for neuropsychiatric disorders, implying that brain structure traits are comparatively "closer to the underlying biology." Genome-wide association studies from large sample sizes allow for the comparison of common variant genetic architectures between traits to test the evidence supporting this claim. Endophenotypes, compared to...

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Identifiers

PMID: 33098356
DOI: 10.1002/hbm.25257
PMCID: PMC8675430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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