Article

BRN2 is a non-canonical melanoma tumor-suppressor

2021-01-13

Abstract excerpt

<h4>ABSTRACT</h4> While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A , have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling is not well understood. The POU domain transcription factor BRN2 is a key regulator of melanoma invasion, yet its role in melanoma initiation rem...

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Literature Corpus work: bd50262f-828a-54da-bbbf-3432b7dd8b3d
DOI: 10.1101/2021.01.13.426554

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