Article

Loss of <i>prdm1a</i> accelerates melanoma onset and progression

2019-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Melanoma is an aggressive, deadly skin cancer derived from melanocytes, a neural crest cell derivative. Melanoma cells mirror the developmental program of neural crest cells in that they exhibit the same gene expression patterns and utilize similar cellular mechanisms, including increased cell proliferation, EMT and migration. Here we studied the role of neural crest regulator PRDM1 in melanoma...

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Literature Corpus work: 1ea359a0-c80d-5505-b0bc-825a8840e0d1
DOI: 10.1101/2019.12.20.884767

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