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Article

Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.

Nature genetics - 1 May 2015

Mann Michael B, Black Michael A, Jones Devin J, Ward Jerrold M, Yew Christopher Chin Kuan, Newberg Justin Y, Dupuy Adam J, Rust Alistair G, Bosenberg Marcus W, McMahon Martin, Print Cristin G, Copeland Neal G, Jenkins Nancy A

Abstract excerpt

Although nearly half of human melanomas harbor oncogenic BRAF(V600E) mutations, the genetic events that cooperate with these mutations to drive melanogenesis are still largely unknown. Here we show that Sleeping Beauty (SB) transposon-mediated mutagenesis drives melanoma progression in Braf(V600E) mutant mice and identify 1,232 recurrently mutated candidate cancer genes (CCGs) from 70 SB-driven melanomas. CCGs...

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Source

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Identifiers

PMID: 25848750
DOI: 10.1038/ng.3275
PMCID: PMC4844184

Genes

BRAF
CEP350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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