Article
Landscape of enhancer disruption and functional screen in melanoma cells.
Genome biology - 30 Oct 2023
Wang Zhao, Luo Menghan, Liang Qian, Zhao Ke, Hu Yuelin, Wang Wei, Feng Xiangling, Hu Bolang, Teng Jianjin, You Tianyi, Li Ran, Bao Zhengkai, Pan Wenhao, Yang Tielong, Zhang Chao, Li Ting, Dong Xiaobao, Yi Xianfu, Liu Ben, Zhao Li, Li Miaoxin, Chen Kexin, Song Weihong, Yang Jilong, Li Mulin Jun
Abstract excerpt
BACKGROUND: The high mutation rate throughout the entire melanoma genome presents a major challenge in stratifying true driver events from the background mutations. Numerous recurrent non-coding alterations, such as those in enhancers, can shape tumor evolution, thereby emphasizing the importance in systematically deciphering enhancer disruptions in melanoma. RESULTS: Here, we leveraged 297 melanoma whole-genome...
Topics
- Humans
- Enhancer Elements, Genetic
- Melanoma
- Mutation