Article

FRA1 drives melanoma metastasis through an actionable transcriptional network

2025-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Transcriptional dysregulation has emerged as a critical driver of melanoma progression, yet the molecular mechanisms governing this process and their potential as therapeutic targets remain inadequately characterized. Here, we identify FRA1 as a potent and actionable driver of melanoma metastasis. FRA1 enhanced both the initial seeding and subsequent outgrowth of metastatic lesions. Comprehensiv...

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Literature Corpus work: d126edc2-748d-5081-a644-e85e635a5608
DOI: 10.1101/2025.06.07.658418

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