Article
BRN2 is a non-canonical melanoma tumor-suppressor.
Nature communications - 17 Jun 2021
Hamm Michael, Sohier Pierre, Petit Valérie, Raymond Jérémy H, Delmas Véronique, Le Coz Madeleine, Gesbert Franck, Kenny Colin, Aktary Zackie, Pouteaux Marie, Rambow Florian, Sarasin Alain, Charoenchon Nisamanee, Bellacosa Alfonso, Sanchez-Del-Campo Luis, Mosteo Laura, Lauss Martin, Meijer Dies, Steingrimsson Eirikur, Jönsson Göran B, Cornell Robert A, Davidson Irwin, Goding Colin R, Larue Lionel
Abstract excerpt
While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling is not well understood. The POU domain transcription factor BRN2 is a key regulator of melanoma invasion, yet its role in melanoma initiation remains unknown. Here,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.