Article

Uncovering Minimal Pathways in Melanoma Initiation

2023-12-10

Abstract excerpt

<h4>ABSTRACT</h4> Cutaneous melanomas are clinically and histologically heterogeneous. Most display activating mutations in Braf or Nras and complete loss of function of one or more tumor suppressor genes. Mouse models that replicate such mutations produce fast-growing, pigmented tumors. However, mice that combine Braf activation with only heterozygous loss of Pten also produce tumors and, as we show here, in...

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Literature Corpus work: 02549a6b-0b02-56af-9a61-5432980f77cd
DOI: 10.1101/2023.12.08.570336

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