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Article

Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation.

Molecular and cellular biology - 1 Apr 2012

Berlin Irina, Denat Laurence, Steunou Anne-Lise, Puig Isabel, Champeval Delphine, Colombo Sophie, Roberts Karen, Bonvin Elise, Bourgeois Yveline, Davidson Irwin, Delmas Véronique, Nieto Laurence, Goding Colin R, Larue Lionel

Abstract excerpt

MITF-M and PAX3 are proteins central to the establishment and transformation of the melanocyte lineage. They control various cellular mechanisms, including migration and proliferation. BRN2 is a POU domain transcription factor expressed in melanoma cell lines and is involved in proliferation and invasion, at least in part by regulating the expression of MITF-M and PAX3. The T361 and S362 residues of BRN2, both in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22290434
DOI: 10.1128/MCB.06257-11
PMCID: PMC3302439

Genes

MITF
PAX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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