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Article

BRN2, a POUerful driver of melanoma phenotype switching and metastasis.

Pigment cell & melanoma research - 1 Jan 2019

Fane Mitchell E, Chhabra Yash, Smith Aaron G, Sturm Richard A

Abstract excerpt

The POU domain family of transcription factors play a central role in embryogenesis and are highly expressed in neural crest cells and the developing brain. BRN2 is a class III POU domain protein that is a key mediator of neuroendocrine and melanocytic development and differentiation. While BRN2 is a central regulator in numerous developmental programs, it has also emerged as a major player in the biology of...

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Identifiers

PMID: 29781575
DOI: 10.1111/pcmr.12710

Genes

MITF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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