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Article

MITF and BRN2 contribute to metastatic growth after dissemination of melanoma

1 Sept 2017

Abstract excerpt

Melanoma tumors are highly heterogeneous, comprising of different cell types that vary in their potential for growth and invasion. Heterogeneous expression of the Microphthalmia-associated Transcription Factor (MITF) and the POU domain transcription factor BRN2 (POU3F2) has been found in malignant melanoma. Changing expression of these transcription factors as the disease progresses has been linked to the...

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Share to Cutaneous Melanoma Detection and Management
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PMID: 28883623
DOI: 10.1038/s41598-017-11366-y

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