RIPOR2 promotes multinucleation of melanoma cells downstream of the RAS/ERK oncogenic pathway

Abstract excerpt

<h4>Summary</h4> One-third of skin melanomas arise from melanocytic nevi, benign skin lesions composed of clustered melanocytes. Benign nevi are associated with overactivation of the mitogen-activated protein kinase RAS/ERK pathway, resulting from driver mutations, most commonly in the BRAF or NRAS gene. However, this overactivation in melanocytes is insufficient to induce melanoma formation, as only a minority...

Topics

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• Gene Expression Regulation, Neoplastic
• Melanoma
• MicroRNAs
• Mutation
• Polymorphism, Single Nucleotide
• Proto-Oncogene Proteins B-raf
• Receptors, Notch
• Up-Regulation

Identifiers and source

Literature Corpus work

23c16614-6e2f-52b4-9ff0-966293262d33

DOI

10.1101/2025.06.26.661696