Article

Esophageal adenocarcinoma relapse after chemoradiation is dominated by a basal-like subtype

2025-02-01

Abstract excerpt

<h4>Summary</h4> Neoadjuvant chemoradiation therapy (RCT) is a frequently used treatment regimen for esophageal adenocarcinoma (EAC); however, the response varies dramatically, and resistance is a clinical challenge. We aimed to identify the molecular mechanisms underlying RCT resistance. We established a mouse xenograft RCT model with human EAC cell lines representing different response groups, and tested enhanc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd30148a-f2cb-5a87-8e41-99d384c904f5
DOI: 10.1101/2025.01.28.635332

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Esophageal adenocarcinoma relapse after chemoradiation is dominated by a basal-like subtypeDOI 10.1101/2025.01.28.635332Read

Evolution of genome and immunogenome in esophageal squamous cell carcinomas driven by neoadjuvant chemoradiotherapySemantic proximity Read

NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages drive chemoradiotherapy resistance in esophageal squamous cell carcinomaSemantic proximity Read

Multiomic Landscape of Esophageal Squamous Cell Carcinoma: Molecular Profiles and Predictors of Neoadjuvant Chemoradiotherapy Responsiveness and ResistanceSemantic proximity Read

YTHDF1 promotes radio-resistance and regulates the repair of DNA double-strand breaks in ESCCSemantic proximity Read

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinomaSemantic proximity Read

Identification of Radioresponsive Genes in Esophageal Cancer from Longitudinal and Single Cell Exome Sequencing.Semantic proximity Read

Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instabilitySemantic proximity Read

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.Semantic proximity Read

Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomicsSemantic proximity Read

Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy.Semantic proximity Read

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of oesophagael adenocarcinomaSemantic proximity Read

Genomic analysis of response to neoadjuvant chemotherapy in esophageal adenocarcinomaSemantic proximity Read