Article

Genomic analysis of response to neoadjuvant chemotherapy in esophageal adenocarcinoma

2021-03-28

Abstract excerpt

Neoadjuvant therapy followed by surgery is the standard of care for locally advanced esophageal adenocarcinoma (EAC). Unfortunately, response to neoadjuvant chemotherapy (NAC) is poor (<20%), as is the overall survival benefit at 5 years (5%). The EAC genome is complex and heterogeneous between patients, and it is not yet understood whether specific mutational patterns may result in chemotherapy sensitivity or res...

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Literature Corpus work: b590c8b9-d4f3-54fd-bd41-2919081d9536
DOI: 10.1101/2021.03.26.437144

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