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Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma

14 May 2025

Abstract excerpt

Locally advanced esophageal adenocarcinoma remains difficult to treat and the ecological and evolutionary dynamics responsible for resistance and recurrence are incompletely understood. Here, we performed longitudinal multiomic analysis of patients with esophageal adenocarcinoma in the MEMORI trial. Multi-region multi-timepoint whole-exome and paired transcriptome sequencing was performed on 27 patients before,...

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PMID: 40369175
DOI: 10.1038/s43018-025-00955-w

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