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Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics

11 Aug 2023

Abstract excerpt

Preoperative neoadjuvant therapy combined with surgical resection is the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, more than half of patients having a partial response to neoadjuvant therapy, which is considered as a therapy-resistant phenotype and the mechanism is still unclear. The heterogeneity of the ESCC with surgery alone therapy were characterized by...

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PMID: 37563120
DOI: 10.1038/s41392-023-01518-0

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