Article
Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.
Nature genetics - 1 Oct 2016
Secrier Maria, Li Xiaodun, de Silva Nadeera, Eldridge Matthew D, Contino Gianmarco, Bornschein Jan, MacRae Shona, Grehan Nicola, O'Donovan Maria, Miremadi Ahmad, Yang Tsun-Po, Bower Lawrence, Chettouh Hamza, Crawte Jason, Galeano-Dalmau Núria, Grabowska Anna, Saunders John, Underwood Tim, Waddell Nicola, Barbour Andrew P, Nutzinger Barbara, Achilleos Achilleas, Edwards Paul A W, Lynch Andy G, Tavaré Simon, Fitzgerald Rebecca C
Abstract excerpt
Esophageal adenocarcinoma (EAC) has a poor outcome, and targeted therapy trials have thus far been disappointing owing to a lack of robust stratification methods. Whole-genome sequencing (WGS) analysis of 129 cases demonstrated that this is a heterogeneous cancer dominated by copy number alterations with frequent large-scale rearrangements. Co-amplification of receptor tyrosine kinases (RTKs) and/or downstream...
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