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Article

Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy.

Cancer discovery - 1 Aug 2015

Murugaesu Nirupa, Wilson Gareth A, Birkbak Nicolai J, Watkins Thomas, McGranahan Nicholas, Kumar Sacheen, Abbassi-Ghadi Nima, Salm Max, Mitter Richard, Horswell Stuart, Rowan Andrew, Phillimore Benjamin, Biggs Jennifer, Begum Sharmin, Matthews Nik, Hochhauser Daniel, Hanna George B, Swanton Charles

Abstract excerpt

UNLABELLED: Esophageal adenocarcinomas are associated with a dismal prognosis. Deciphering the evolutionary history of this disease may shed light on therapeutically tractable targets and reveal dynamic mutational processes during the disease course and following neoadjuvant chemotherapy (NAC). We exome sequenced 40 tumor regions from 8 patients with operable esophageal adenocarcinomas, before and after...

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Identifiers

PMID: 26003801
DOI: 10.1158/2159-8290.CD-15-0412
PMCID: PMC4529488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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