Article

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of oesophagael adenocarcinoma

2023-04-13

Abstract excerpt

<title>Abstract</title> <p>Locally advanced oesophageal adenocarcinoma (EAC) remains difficult to treat because of common resistance to neoadjuvant therapy and high recurrence rates. The ecological and evolutionary dynamics responsible for treatment failure are incompletely understood. Here, we performed a comprehensive multi-omic analysis of samples collected from EAC patients in the MEMORI clinical trial, revea...

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Literature Corpus work: e1583755-56ed-53ba-a692-35c3fa5f3474
DOI: 10.21203/rs.3.rs-2738048/v1

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