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Article

YTHDF1 promotes radio-resistance and regulates the repair of DNA double-strand breaks in ESCC

2023-01-11

Abstract excerpt

The morbidity and mortality of esophageal carcinoma (ESCA) patients is high in China for which radical radiotherapy remains the frontline treatment. Radio-resistant patients show high rates of relapse and poor overall survival (OS). In this study, we report high YTHDF1 expression in ESCA patients that is associated with radio-resistance and poor OS. Accordingly, YTHDF1 silencing improved the radio-sensitivity of E...

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Identifiers and source

Literature Corpus work
10995bb3-cfe5-54f5-bb3b-2d3c41487522
DOI
10.21203/rs.3.rs-2454820/v1
Open publication

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