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NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages drive chemoradiotherapy resistance in esophageal squamous cell carcinoma

2026-02-21

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) is among the most aggressive cancers, with low rates of durable response to chemoradiotherapy and limited therapeutic options for relapsed disease. To uncover mechanisms of treatment resistance and relapse, we performed comprehensive multi-omics profiling of >100 pre-treatment and post-relapse ESCC tumors from a prospective clinical trial ( NCT04694391 ), integrating whol...

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Literature Corpus work
16d8f8d2-9f40-551e-aba6-73dd4b4a17a0
DOI
10.64898/2026.02.20.706928
Open publication

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NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages drive chemoradiotherapy resistance in esophageal squamous cell carcinomaDOI 10.64898/2026.02.20.706928
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