Article
Identification of Radioresponsive Genes in Esophageal Cancer from Longitudinal and Single Cell Exome Sequencing.
International journal of radiation oncology, biology, physics - 15 Nov 2020
Yang Ling, Zhang Xiaoyan, MacKay Matthew, Foox Jonathan, Hou Qiang, Zheng Xiaoli, Zhou Rongjing, Huang Ming, Jing Zhao, Mason Christopher E, Wu Shixiu
Abstract excerpt
PURPOSE: The majority (70%) of the esophageal squamous cell carcinoma (ESCC) cases in the world occur in China, where radiation therapy is the most common treatment. Yet the majority of ESCC patients still relapse. METHODS AND MATERIALS: To better understand the genetic basis of radiation therapy resistance for ESCC, we performed longitudinal, whole-exome sequencing throughout radiation therapy on 42 patient...
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