Article

Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome

2020-08-14

Abstract excerpt

<h4>ABSTRACT</h4> Regulating desired loci in the genome with sequence-specific DNA-binding molecules is a major goal for the development of precision medicine. Pyrrole–imidazole (Py–Im) polyamides are synthetic molecules that can be rationally designed to target specific DNA sequences to both disrupt and recruit transcriptional machinery. While in vitro binding has been extensively studied, in vivo effects are...

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Literature Corpus work: bc99646b-041d-5cd1-9d97-544900b35936
DOI: 10.1101/2020.08.13.249730

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