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Article

Sequence specific suppression of androgen receptor–DNA binding in vivo by a Py-Im polyamide

22 Feb 2019

Abstract excerpt

The crucial role of androgen receptor (AR) in prostate cancer development is well documented, and its inhibition is a mainstay of prostate cancer treatment. Here, we analyze the perturbations to the AR cistrome caused by a minor groove binding molecule that is designed to target a sequence found in a subset of androgen response elements (ARE). We find treatment with this pyrrole-imidazole (Py-Im) polyamide...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 30838415
DOI: 10.1093/nar/gkz153

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