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Article

Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome.

PloS one - 1 Jan 2016

Lin Jason, Hiraoka Kiriko, Watanabe Takayoshi, Kuo Tony, Shinozaki Yoshinao, Takatori Atsushi, Koshikawa Nobuko, Chandran Anandhakumar, Otsuki Joe, Sugiyama Hiroshi, Horton Paul, Nagase Hiroki

Abstract excerpt

Pyrrole-imidazole polyamides are versatile DNA minor groove binders and attractive therapeutic options against oncological targets, especially upon functionalization with an alkylating agent such as seco-CBI. These molecules also provide an alternative for oncogenes deemed "undruggable" at the protein level, where the absence of solvent-accessible pockets or structural crevices prevent the formation of...

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Share to Antineoplastic Agents, Alkylating
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 27798693
DOI: 10.1371/journal.pone.0165581
PMCID: PMC5087912

Genes

KRAS

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Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome.PMID 27798693Read ↗

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