Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism

Abstract excerpt

<h4>ABSTRACT</h4> By combining in-silico , biophysical and in-cellulo experiments, we decipher the topology, physical and potential biological properties of hybrid-parallel nucleic acids triplexes; an elusive structure at the basis of life. We found that hybrid triplex topology follows a stability order: r(Py)-d(Pu)·r(Py)> r(Py)-d(Pu)·d(Py)> d(Py)-d(Pu)·d(Py)> d(Py)-d(Pu)·r(Py). The r(Py)-d(Pu)·d(Py) triplex is...

Topics

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• Computational Biology
• Gene Expression Regulation
• Genome, Human
• Genomics
• Nucleic Acid Conformation
• Oligonucleotides
• Probability
• Promoter Regions, Genetic

Identifiers and source

Literature Corpus work

7e26bd04-bab4-5a99-a776-eddeab0c7aff

DOI

10.1101/2024.05.28.596189