Article

Mapping the Human Proteome with Physical Access to DNA

2024-04-04

Abstract excerpt

In a human cell, DNA is packed in histones, RNA, and chromatin-associated proteins, forming a cohesive gel. At any given moment, only a specific subset of the proteome has physical access to the DNA and organizes its structure, transcription, replication, repair and other molecular functions essential to the way the genome is read and maintained. We have developed a ‘zero-distance’ photo-crosslinking approach to q...

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Literature Corpus work: 703e3058-dc03-5428-bae2-b8dae322757d
DOI: 10.1101/2024.04.04.588092

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