Article

Selective Stabilization of HRAS2 i-Motif DNA by TMPyP4: A Multimodal Biophysical and Thermodynamic Investigation

2026-04-12

Abstract excerpt

<h4>ABSTRACT</h4> I-motif (iM) DNA structures, formed by cytosine-rich sequences, are increasingly acknowledged for their involvement in gene regulation, maintenance of genomic stability, and their emerging potential as therapeutic targets, particularly in cancer. Despite their biological relevance, the discovery of selective small-molecule probes that can specifically recognize and interact with iM DNA remains a...

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Literature Corpus work: afc282a9-8a21-546f-800a-8caaed04cbef
DOI: 10.64898/2026.04.08.717182

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