Article

Distinct alpha-synuclein strains derived from Parkinson’s disease patient tissues trigger differential inclusion pathology in a novel biosensor cell model

2025-04-03

Abstract excerpt

<h4>Background</h4> α-Synuclein (αSyn) can misfold and aggregate to form fibrillar ß-sheet-rich aggregates (“strains”) that are phosphorylated (p-αSyn) and deposited into intracellular inclusions in the brain, the pathological hallmark of synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Previously, we reported that seed amplification assays...

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Literature Corpus work: 2d635907-f420-5c70-ae80-57fcdeaf411e
DOI: 10.1101/2025.04.01.646513

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