Article

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

2023-09-29

Abstract excerpt

<h4>ABSTRACT</h4> Synucleinopathies are characterized by the accumulation and propagation of α-synuclein (α-syn) aggregates throughout the brain, leading to neuronal dysfunction and death. Understanding how these aggregates propagate from cell to cell in a prion-like fashion thus holds great therapeutic promises. Here, we focused on understanding the cellular processes involved in the entry and accumulation of pa...

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Literature Corpus work: 703c0e50-678a-5d6b-8e55-73f8960f7998
DOI: 10.1101/2023.09.29.560170

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